Andexxa2/14/2024 ![]() ![]() In the ANNEXA-4 study (Andexanet Alfa, a Novel Antidote to the Anticoagulation Effects of FXa Inhibitors), patients with acute major bleeding (ICrH and gastrointestinal bleeding primarily) received andexanet. 11 This was associated with a similarly rapid increase in thrombin generation that persisted up to 22 hours after the completion of andexanet. 10 Studies in healthy volunteers have shown that administration of andexanet resulted in a median >92% reduction from baseline in anti-FXa activity of apixaban and rivaroxaban, with a rapid onset of effect within minutes after the start of administration. ![]() 8, 9 Andexanet is a modified, recombinant, enzymatically inactive form of FXa, which binds and sequesters FXa inhibitors, thereby neutralizing their anti-FXa activity. 6, 7Īndexanet alfa (US adopted name: coagulation factor Xa inactivated-zhzo) is a specific reversal agent approved by the US Food and Drug Administration and the European Medicines Agency for uncontrolled or life-threatening bleeding related to the oral FXa inhibitors apixaban and rivaroxaban. ![]() 4, 5 Despite their superior safety, ≈0.3% to 0.5% of patients receiving FXa inhibitors suffer intracranial hemorrhage (ICrH) annually, 1–3 which is associated with 30-day mortality rates of 27% to 48%. Large clinical trials have demonstrated that FXa inhibitors are as effective and safer than warfarin 1–3 and are now widely recommended by guidelines. ![]() Customer Service and Ordering InformationįXa (factor Xa) inhibitors have become widely used for the prevention and treatment of venous thromboembolism, stroke prevention in atrial fibrillation, and management of patients with coronary artery disease or peripheral artery disease.Stroke: Vascular and Interventional Neurology.Journal of the American Heart Association (JAHA).Circ: Cardiovascular Quality & Outcomes.Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB). ![]()
0 Comments
Leave a Reply.AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |